Inspired by the works of his Academy Award-winning father, Begley became an actor. He first came to audiences' attention for his portrayal of Dr. Victor Ehrlich on the long-running hit television series St. Elsewhere, for which he received six Emmy nominations. Since then, Begley has moved easily between feature films, television and theatre projects. He has appeared in several Christopher Guest films, including A Mighty Wind, Best In Show and For Your Consideration. Recent feature film credits include Woody Allen's Whatever Works with Larry David, as well as Pineapple Express with Seth Rogan. Begley has also appeared in Batman Forever, The Accidental Tourist and The Inlaws.
On television, Begley has had recurring roles on Six Feet Under and Arrested Development. He has also guest starred on such series as The West Wing, The Practice, and Boston Legal. Most recently, Begley was featured in Gary Unmarried, The New Adventures Of Old Christine, and Party Down.
Begley also starred in the West Coast premiere of David Mamet's Cryptogram at the Geffen Playhouse, in a role that he first performed in Boston and then in New York.
This talented actor has also directed several episodes of the hit TV series NYPD Blue as well as a stage play that he wrote and directed called Cesar and Ruben that won a Nos Otros Award and four Valley Theater League awards. The play was re-launched at Santa Monica City College in Los Angeles for a 2011 fall run.